Published: 15 April, 2019 | Volume 2 - Issue 1 | Pages: 018-026
Figure 1:
Left. Peripheral blood smears showing normal sized platelets in control (A) and large platelets in essential thrombocythemia (ET). Bone marrow smears (middle panels) showing normal sized megakaryocytes in control (left) and large megakaryocytes in ET (right). Bone marrow biopsy with hypercellular bone marrow histology (80% lower panels left ) due to increased erythropoietic and megakaryocytic (EM) proliferation showing increase of clustered large mature megakaryocytes with hyper-lobulated nuclei in JAK2V617F mutated ET with features of PV (low serum EPO, increased LAP score) consisted with prodromal PV. Right. Bone marrow biopsy showing a hypercellular bone marrow (90%) due to increased erythropoietic, megakaryocytic and granulocytic (EMG) proliferation with increase of clustered large mature megakaryocytes with hyper-lobulated nuclei and reticulin fibers grade 1 in JAK2V617F mutated classical PV and thrombocythemia with platelet of 1296x109/L.
Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001003 Cite this Article Read Full Article PDF
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